Interestingly, a p53-independent overexpression of the p53 target gene TP53-induced glycolysis and apoptosis regulator (TIGAR) is often observed in tumor cells, causing an up-regulation of the oxidative and non-oxidative PPP which are important for the production of NADPH and ribose-5-phosphate (an anabolic intermediate needed for nucleotide production), respectively.47 The gene discussed is TP53; the disease is neoplasm.