A new protocol targeting cancer stem cells composed of antiangiogenic antibody Bevacizumab and the mTOR/hypoxia-inducible factor inhibitor Temsirolimus combined with antiproliferation liposomal doxorubicin has shown complete/partial pathological response as an adjuvant chemotherapy in phase I clinical trials in 2/5, 40% [10], and 5/12, 42% [11], of patients with a diagnosis of MBC. Here, MTOR is linked to cancer.