The pathological diagnoses were (1) invasive ductal carcinoma of pectoral breast, grade 2, ypT1c, with partial chemotherapy response, ER+/PR+/Her2−, and (2) axillary breast metaplastic carcinoma with vascular invasion, grade 3, ypT3, ER−/PR−/Her2−. The gene discussed is ESR1; the disease is invasive ductal breast carcinoma.