IL-8 promotes the growth of pancreatic tumors as a primary mediator of angiogenesis (32,36), and IL-8 expression levels have been observed to correlate with angiogenesis, tumorigenicity and metastasis in numerous xenograft and orthotopic in vivo tumor models, including pancreatic cancer models (34). This evidence concerns the gene CXCL8 and pancreatic neoplasm.