Pre-NAC expression, post-NAC expression and the expression change following NAC of p-mTOR and p-4E-BP1 was evaluated to identify correlations with patient or tumor characteristics, including patient age at diagnosis, tumor grade and stage, estrogen receptor status, and HER2 status of tumors from core biopsy at diagnosis, as well as the tumor stage and presence of axillary metastases from resection pathology. Here, ERBB2 is linked to neoplasm.