As shown in Tables III and IV, an increased level of Dll4 expression was shown to be an independent prognostic predictor of OS (P=0.021) and PFS (P=0.034) times, in addition to the presence of tumor metastasis (OS, P=0.001), tumor stage, tumor grade (OS, P=0.045) and high expression levels of VEGFR-2. This evidence concerns the gene DLL4 and neoplasm.