By using western blotting and IHC, 60 cases of glioma specimens were compared with 10 cases of control brain tissues to identify the following: i) In the control group, the expression of ADAM17 protein expression was non-detectable or low, whereas it was highly expressed in the glioma groups; the protein expression of ADAM17 increased with an increase in glioma malignancy. The gene discussed is ADAM17; the disease is central nervous system cancer.