VTCN1 and bladder transitional cell carcinoma: In the present study, B7-H4 expression was shown to be closely associated with increased TNM stage and histological grade in the bladder urothelial carcinoma samples, as the positive expression rate in the myometrial invasion group was significantly higher than that of the non-muscle-invasive group, and the positive expression rate in the high-grade group was significantly higher than that in the low-grade group.