In certain cases, at the level of the larynx, scores of 2 were observed in addition to the presence of two distribution models, which were as follows: i) Homogeneous distribution, all the cells in the tumor area were positive for CK5 labeling; and ii) heterogeneous distribution, the CK5-positive cells were prevalent at the periphery of the tumor areas. The gene discussed is KRT5; the disease is neoplasm.