IGF1R and esophageal squamous cell carcinoma: The current study demonstrated that IGF-1r siRNA, which can effectively reduce IGF-1r expression in both TE-1 and Eca-109 cells, may enhance the radiation sensitivity of ESCC tumors and increase the therapeutic effects of radiation both in vitro and in vivo. These results provide strong evidence that targeted use of siRNA may enable the development of new therapeutic strategies for the clinical treatment of ESCC patients.