CYP2C8 and malaria: This study identified that 4.6% of participants were homozygotes for the slow metabolizer allele (CYP2C8*2) representing a significant population at high risk to amodiaquine toxicity due to amodiaquine accumulation, taking into account artesunate-amodiaquine is an alternative to artemether-lumefantrine in the treatment of uncomplicated malaria in Tanzania and other sub-Saharan African countries [1, 58].