References were identified through searches of NLM PubMed for articles in English, French, Spanish, Italian, and German using the terms ‘primaquine’, ‘pamaquine’, ‘plasmoquine’, ‘G6PD’ and ‘G6PD deficiency’ and the limit ‘human’, with no time limit. This evidence concerns the gene G6PD and hyperinsulinemic hypoglycemia, familial, 4.