TGF-B1 will perform elastogen mobility and deposition of collagen I fibers in TADF’s (fibroblasts derived from tunica albuginea) in a given time and dose (Ng, 2009; Valente et al., 2003) Pretreatment with pentoxifylline decreases significantly elastogen by TGF-B1 and deposition of collagen fibers in TADF’s in people with and without Peyronie’s disease (Brant, Dean, & Lue, 2006; Lin, 2005). Here, TGFB1 is linked to Abnormality of connective tissue.