In another study by Shindel et al. (2009) had been finally concluded, as regards metabolism and production of collagen and elastin affect regulatory TGF-B1 at TADF cells, the inhibitory effect of pentoxifylline on TGF-B1 causes reduction in the secretion and production of elastin and collagen and these suggestive changes are the beneficial role of pentoxifylline in the treatment of Peyronie’s disease, is consistent. This evidence concerns the gene TGFB1 and Abnormality of connective tissue.