TGFB1 and Peyronie disease: In another study by Shindel et al. (2009) had been finally concluded, as regards metabolism and production of collagen and elastin affect regulatory TGF-B1 at TADF cells, the inhibitory effect of pentoxifylline on TGF-B1 causes reduction in the secretion and production of elastin and collagen and these suggestive changes are the beneficial role of pentoxifylline in the treatment of Peyronie’s disease, is consistent.