Pretreatment with pentoxifylline reduces deposition of collagen fibers and elastogen in TADF’s that are exposed to TGF-B1 that this effect is a useful role of pentoxifylline in the treatment of Peyronie’s disease (Bivalacqua et al., 2000; Mulhall et al., 2002). The gene discussed is TGFB1; the disease is Peyronie disease.