Although the precise function of LAMP3 is unknown, recent in vitro and in vivo studies suggest that LAMP3 may be important for tumor metastasis and resistance to therapy: LAMP3 protein was overexpressed in cancer cells from many organs, including cervix, breast, ovary, colon and liver [12]; LAMP3 induces migration and invasion of tumor cells in vitro [13-14]; LAMP3 expression has been associated with resistance to chemotherapy and radiotherapy [15-17]; finally, LAMP3 expression has been associated with lymph node metastasis and poor overall survival [18-20]. This evidence concerns the gene LAMP3 and metastatic malignant neoplasm in the lymph nodes.