TP53 and colonic neoplasm: Thus far, only two studies have investigated the potential role of LAMP3 in gastrointestinal tumors: Ishigami et al found that the presence of intratumoral LAMP3+ (CD208+) mature interdigitating dendritic cells (IDCs) was inversely correlated with patients' postoperative outcome in GC [28]; Adamsen et al identified LAMP3 as a novel TP53 downstream target gene in colon cancer cells [29].