CTSD and diffuse large B-cell lymphoma: Significantly up-regulated genes in DLBCL samples included CTSD, DRAM1 and TGM2. CTSD and DRAM1 are lysosomal proteins which regulate the autophagic flux through the lysosome [30, 41], while TGM2 is involved in autophagy-dependent clearance of ubiquitinated proteins [42].