At the age of 11 years, increased levels of ACTH (150 pg/ml; n.v. 10–130) and renin (184 pg/ml; n.v. 1.8-3.3 pg/ml), with reduced cortisol peak (108 ng/ml) after ACTH stimulation test, associated with presence of anti-adrenal cortex, 17- and 21-hydroxylase antibodies, led to the diagnosis of AD; therefore, glucocorticoid and mineralcorticoid replacement therapy were started. Here, POMC is linked to Alzheimer disease.