In line with the observation of high levels of HIF-1α and OATP staining in human PCa samples, we surveyed HIF-1α and OATP2B1 protein expression in multiple types of paired cancer-adjacent normal and cancerous canine (breast, duodenal, liver, lung, colon and epidermis sarcoma) and human (lung, colon, prostate, breast, liver and kidney) tissues by double quantum dots labeling (QDL) analysis. The gene discussed is SLCO2B1; the disease is sarcoma.