Besides, Na+/H+ antiporters and arginine decarboxylase may also be used for acid stress, and several genes encoding heavy metal exporting proteins and those for oxidative stress were also expressed (Figure 3b and Supplementary Table 5), indicating multiple stress mechanisms used for FKB7 to adapt to the extreme AMD conditions (Table 1). This evidence concerns the gene AZIN2 and age-related macular degeneration.