EGFR and cancer: Consistent with endogenous BIM expression in cancer cells being a determinant of apoptotic responsiveness to kinase inhibitors, including EGFR inhibitors [40], we observed that the two lines that did not show evidence of apoptosis upon combined drug traetment (MDA-MB-436 and MDA-MB-435S) expressed the lowest amount of endogenous BIM protein (Suppl.