The second most common mutation is BRAFV600K substituting lysine for valine, that represents 5–6% (GTG>AAG), followed by BRAFV600R (GTG>AGG), an infrequent two-nucleotide variation of the predominant mutation, BRAFV600′E2′ (GTG>GAA), and BRAF V600D (GTG>GAT) [Catalogue of Somatic Mutations in Cancer (COSMIC) [http://www.sanger.ac.uk/cosmic]. This evidence concerns the gene BRAF and cancer.