We have previously reported that everolimus robustly inhibits mTORC1 signaling in our ALL model.[10] Phosphorylation of 4E-BP1 was significantly inhibited by BEZ235 and BGT226 in vivo 2 hours after administration (p<0.01 for both agents) but increased by 24 hours, remaining significantly lower than controls for BGT226 only (p=0.02, Figure 5B). Here, EIF4EBP1 is linked to acute lymphoblastic leukemia.