ICMT and cancer: Among them, Rac1 and ICMT were selected for further experimental validation (Supplementary Table 1), because Rac1 is frequently activated in tumor tissues and promotes cancer metastasis [16-18], while ICMT plays an essential role in activating Rho GTPase [19], including Rac1, and inhibition of ICMT leads to decrease of GTP-bound Rac1 [20].