Furthermore, as shown in Fig. 2D and Supplementary Fig. S3, the reduction in cell viability caused by CBX8 knockdown was mostly rescued when p53 was simultaneously knocked down in HCT116 and HT29 cells, demonstrating that the inhibitory effect of CBX knockdown on cell proliferation is mostly p53-dependent in CRC cells. This evidence concerns the gene CBX8 and colorectal carcinoma.