CBX8 and colorectal carcinoma: Next, we sought to determine the target involved in CBX8-mediated motility in CRC, and the up-regulation of ITGB4 after CBX8 knockdown caught our attention (Fig. 2A), as ITGB4 is a key component for both actin cytoskeleton rearrangements and focal adhesions and plays a critical role in cell motility [24–28].