Furthermore, using DLD1 cell line, which has lower CBX8 protein level compared with other CRC cell lines (Supplementary Fig. S1B), the cell viability was not changed when CBX8 was stably overexpressed in this cell line in vitro, and the CRC xenograft tumor growth of this stable transfectant was not impaired neither in vivo (Supplementary Fig. S2C, S2D, S2E). Here, CBX8 is linked to neoplasm.