CBX8 and colorectal carcinoma: In order to determine the functions of CBX8 in CRC, we generated stable transfectants of two specific shRNAs targeting CBX8 in two CRC cell lines, HCT116 and HT-29 (Fig. 1D), because both cell lines have higher CBX8 protein levels compared with other CRC cell lines and CCD-18-Co, a transformed colonic cell line (Supplementary Fig. S1B).