TP53 and neoplasm: More importantly, using both HCT116-WT and HCT116-p53−/− cell lines, as shown in Fig. 2E, 2F, the CRC xenograft tumor growth was clearly impaired in HCT116-WT cells, but not in HCT116-p53−/− cells, in vivo when CBX8 was stably knocked down in these cells, reinforcing the notion that the inhibition of CBX8 knockdown on cell growth mainly relies on p53 in CRC cells.