RSA59 infection of the mouse spinal cord is further marked by increased expression of genes involved in IFN signaling including immunity related GTPase (Irgm2|Igtp, Irgm1|Igtp), Interferon inducible protein (Guanylate binding protein; GBP2, GBP3, GBP4, GBP6, GBP8, GBP9), macrophage activation 2 like protein (GBP10), interferon inducible GTPase (IiGP1), and T cell related GTPase. The gene discussed is GBP4; the disease is infection.