In univariate analysis, seventeen factors were significantly associated with life-threatening LRTI and these were as follows: faltering growth, presence of comorbidities i.e. CHD, CLD and genetic/metabolic disease, symptoms of being afebrile, shortness of breath, apnoea and lethargy, previous lung infection, previous hospital admission, hypoxia (<92%), not attending nursery, positive NPS culture CRP, neutrophil count, lymphocyte count and bicarbonate level (Table 3). This evidence concerns the gene CRP and Other metabolic disease.