Other RTKs, such as Axl, IGF1R and EphB2/Receptor, reported to be involved in malignant glioma biology, were also identified; Integrins αυβ3and αυβ5 (ITGAV, ITGB3 and ITGB5), that are important for glioma cell migration and angiogenesis; Target proteins that were overexpressed in primary explants of human malignant gliomas relative to normal and nonneoplastic brain tissues were glycoprotein NMB (GPNMB), tenascin (TNC) and interleukin-13 receptor α2 subunit (IL13RA2). This evidence concerns the gene EPHB2 and central nervous system cancer.