Among those weakly expressed or barely detected in most human normal tissues and cells, we found well-known GBM targets (IL13RA2, PTPRZ1 and TNC) as well as new integral plasma membrane glycoproteins that were not reported by previous proteomic or transcriptomic analyses (ANGPTL2, ICAM1, IL1RAP, ITGB8, LGALS3BP, SLC1A3 and THBD). The gene discussed is IL1RAP; the disease is glioblastoma.