LIN28 induces pluripotency when expressed in somatic fibroblasts along with OCT4, SOX2 and KLF4. LIN28B, as a homologue of LIN28, was first cloned from and shown to be overexpressed in human hepatocellular carcinoma cells and clinical samples in 2006 [2]. This evidence concerns the gene LIN28A and hepatocellular carcinoma.