IL-18Rα may have additional IL-18-independent functions in TB that IL-18R signaling on antigen-presenting cells was critical for the secretion of IL-23p40 and the subsequent maintenance of IL-17-secreting T cells [26], and the IL-23/IL-17 axis also contributes to IFN-γ production in the control of M. tuberculosis infection [27]. This evidence concerns the gene IL17A and tuberculosis.