Another line of evidence is the association between CM and a homozygous mutation in ICAM-1 in Kilifi, Kenya, named ICAM-1Kilifi[19], although it should be noted that other studies such as those in the Gambia and Thailand have not shown an association between ICAM-1Kilifi and severe malaria [20], [21], [12]. This evidence concerns the gene ICAM1 and cutaneous mastocytosis.