The induction of GRP78 by stress leads to an increase in GRP78 in the endoplasmic reticulum compartment, as well as its re-localization to the cell surface of various types of cancer including breast cancer cells (Hs578T, MDA-MB-231, BrCa-MZ-01 and MCF-7) [12, 18]. The gene discussed is HSPA5; the disease is breast cancer.