Most notably, in obesity both the local AT and circulating levels of inflammatory mediators, such as TNFα, IL-6, IL-1β, MCP-1, leptin and many others (reviewed by [58,59]), are elevated, while levels of adiponectin, an anti-inflammatory adipokine, are decreased [61]. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.