NFKB1 and cancer: Moreover, aberrant NFκB signaling is proposed to be one of the mechanisms through which chronic inflammation leads to cancer, as NFκB activation promotes tumorigenesis by inhibiting apoptosis (via activation of Bcl2, Bcl-xL, cFLIP and other genes) and increasing cell proliferation by regulating expression of cyclinD1, cyclinE, CDK2, and c-Myc [174].