MAPK3 and breast cancer: In MCF-7 BC cells, microarray analysis demonstrated that adiponectin represses expression of multiple important genes that regulate cell cycle (MAPK3 and ATM) and apoptosis (BAG1, BAG3, and TP53), as well as potential diagnostic/prognostic markers (ACADS, CYP19A1, DEGS1, and EVL) [250].