There is also strong evidence implicating inflammation in the sequelae of cancer-related fatigue (25) and preliminary studies have shown that high-dose IV vitamin C reduces biomarkers of inflammation, such as C-reactive protein (CRP), tumor necrosis factor (TNF-α), interferon-γ (IFN-γ), and the interleukins IL-1, IL2, IL-6, IL-8, in cancer patients (35, 36). Here, TNF is linked to cancer.