Whether the pathogenic DQB1*06:02-associated autoimmunity is limited to the reductionist transgenic models of MS, or whether GWASs could not distinguish the DQA1*01:02- and DQB1*06:02-related functionally relevant effects on MS risk from the functional effects driven by DRB1*15:01 allele, due to strong LD, would require functional studies with PBLs of HLA-DR15+ MS patients, in particular PBLs reactive against MOBP and/or PLP. This evidence concerns the gene HLA-DRB1 and Autoimmunity.