The HLA-II-Tg mice studies showing that HLA-DRB1*1501-Tg mice are susceptible to myelin basic protein (MBP)- or myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) (8, 9) are also consistent with the primary contribution of DRB1*1501 to MS pathogenesis. The gene discussed is MBP; the disease is myeloid sarcoma.