Immunodominant epitopes in MS are also often encephalitogenic epitopes in relevant susceptible experimental animals [e.g., MBP 89-101 in SJL/J mice (24), PLP 43-64 in Pl/J mice (25), MOG 35-55 in H-2b mice (26, 27), Lewis rats (28) and Rhesus monkeys (29), and MOBP 65-86 in H-2b mice (30)]. The gene discussed is MOBP; the disease is myeloid sarcoma.