HLA-DR2 Tg mice also reacted to MOG 91-110, which is immunodominant in the T-cell response to MOG in rhesus monkeys with MOG-induced EAE (29); HLA-DR4 Tg mice reacted to MOG31–50 and 91–110 and the potential relevance of this latter epitope to MS pathogenesis was confirmed by the study of Forsthuber et al. (37). This evidence concerns the gene MOG and myeloid sarcoma.