However, we recently showed that “humanized” mice expressing DQB1*06:02, but not the DRB1*15:01, genes can develop MS-like disease mediated by autoimmune cells reactive against a CNS protein, myelin oligodendrocytic basic protein (MOBP) (10), which is also an important target antigen for the immune attack in MS. The gene discussed is HLA-DRB1; the disease is myeloid sarcoma.