Accounting for the extent of the axillary lymph node metastases, the standard treatment for the patient in the present case study would usually have been neoadjuvant chemotherapy via administration of anticancer agents, such as anthracycline and taxane (plus the anti-HER2 agent, trastuzumab), followed by surgery and radiation therapy, followed up with administration of trastuzumab as an adjuvant therapeutic agent. Here, ERBB2 is linked to metastatic malignant neoplasm in the lymph nodes.