PIK3CA and cancer: For example, in our study HRAS (P = 5.0 × 10-46), AKT1 (P = 9.5 × 10-26), PIK3CA (P = 5.5 × 10-5), B2M (P = 6.7 × 10-4), and KDM5C (P = 3.5 × 10-3) were predicted to be putative cancer genes using Fisher’s exact test and evidently designated as cancer driver genes according to the 20/20 rule [3].