For colon adenocarcinoma, the somatic mutations in four genes were significantly enriched in protein pocket regions: B2M (P = 3.1 × 10-4), IFNA2 (P = 3.1 × 10-4), VAV3 (P = 6.6 × 10-4), and ETV6 (P = 1.0 × 10-3). The gene discussed is ETV6; the disease is colon adenocarcinoma.