For skin melanoma, somatic mutations in four genes were significantly enriched in their protein pocket regions (Figure 4), including CRP (P = 2.2 × 10-6), NCF1 (P = 6.3 × 10-4), EPO (P = 2.2 × 10-3), and RWDD1 (P = 2.2 × 10-3). Here, CRP is linked to cutaneous melanoma.