Remarkably, the top two most disease correlated modules (light green and light cyan; R-square >0.8; Figure 2A and B) included dysregulated genes previously implicated in neurodevelopmental diseases, such as YWHAE (Miller-Dieker Syndrome) [64], ERC1 (12p13.31 deletion associated developmental delay) [65], and VAV3 (schizophrenia) [66] (Figure 2B). Here, YWHAE is linked to Global developmental delay.