PIK3CG and lung cancer: Although the prevalence and functional relevance of mutations in PI3Ks other than p110α are considered limited it is worth mentioning that significant recurrent mutations have been seen in both PIK3CG (9.7%) and PIK3C2B (12.9%), the gene encoding for the class II isoform PI3K-C2β, in lung cancer (Liu et al., 2012).