PIK3CD and cancer: Interestingly, amongst the distinct cancer models investigated in this study, the authors also reported that treatment with PI-3065, a small molecule inhibitor with selectivity for p110δ, prolonged survival and reduced the incidence of macroscopic metastases in the LSL KRasG12D/+; p53R172H/+; PdxCretg/+ model of PDAC (Ali et al., 2014).