Evidence also suggests that p110γ can be directly involved in cancer cell migration and invasion, as it has been shown in MDA-MB-231 (Brazzatti et al., 2012; Xie et al., 2013) and in melanoma cells (Monterrubio et al., 2009) in response to the chemokine CXCL12. This evidence concerns the gene CXCL12 and cancer.