MAPT and Alzheimer disease: This knowledge is now incorporated in the new diagnostic criteria for MCI, indicating that positive biomarkers of Aβ accumulation (e.g., CSF Aβ42) and neuronal injury (e.g., CSF T-tau and p-tau) confers the highest likelihood that AD pathophysiological processes are the cause of the cognitive dysfunction; and that individuals with this biomarker profile are more likely to decline or progress to dementia due to AD in relatively short periods (Albert et al., 2011).