MAPT and Alzheimer disease: Moreover, p-tau usually shows better performance than T-tau (Mitchell, 2009; Bloudek et al., 2011; van Harten et al., 2011), probably because p-tau is not only a marker of axonal damage and neuronal degeneration, as T-tau, but it is more closely related to AD pathophysiology and the formation of neurofibrillary tangles (Anoop et al., 2010; Holtzman, 2011).