A number of studies have shown that striatal neurons depend on BDNF for survival (Mizuno et al., 1994; Widmer and Hefti, 1994; Nakao et al., 1995; Martınez-Serrano and Bjorklund, 1996; Alcantara et al., 1997; Ivkovic and Ehrlich, 1999; Aggerman and Ernfors, 2003; Grosse et al., 2005; Ventimiglia et al., 1995), and production and delivery of BDNF from cortex to striatum is diminished in HD and animal models of HD (Cattaneo et al., 2001, 2005; Zuccato et al., 2001, 2003, 2005, 2008; Gauthier et al., 2004; Zuccato and Cattaneo, 2007; Reiner et al., 2012b). Here, BDNF is linked to Huntington disease.