Moreover, studies in various mutant mice indicate that diminished cortical production of BDNF harms striatal neurons (Gorski et al., 2003; Baquet et al., 2004; Canals et al., 2004; Saylor et al., 2006; Strand et al., 2007), and intrastriatal BDNF delivery or selective forebrain overexpression of BDNF improves symptoms in transgenic HD mice (Canals et al., 2004; Gharami et al., 2008; Xie et al., 2010; Giralt et al., 2011). Here, BDNF is linked to Huntington disease.