PSEN1 and nervous system disorder: Core analysis of these molecules showed a strong enhancement of neuronal functionality, with top functional terms “neurotransmission” (p = 1.97e-07, APP, GRIK2, KCNMB4, PCDHB10, PCDHB14, PCDHB5, PSEN1), “neurological disease” (p = 7.41e-07, APP, BCL2, CHGB, DPYSL3, ESRRG, GABRA3, GRIK2, LGR5, NTRK2, PLK2, PSEN1, SCN3A, VCAN), “synaptic transmission of cells” (p = 1.52e-06, APP, GRIK2, PCDHB10, PCDHB14, PCDHB5, PSEN1), and “synaptogenesis” (p = 1.93e-06, APP, PCDHB10, PCDHB14, PCDHB5).