CXCL12 and posterior cortical atrophy: In relation to the tumor microenvironment, pathological involvement of the chemokine (C-X-C motif) ligand 12/chemokine (C-X-C motif) receptor 4 (CXCL12/CXCR4) signaling axis has been very well documented in several malignancies, including PCa [13–15].