PIF1 and neoplasm: Slower fork rates were also detected in HCT116 tumour cells (with an activating K-RASG13D mutation) following PIF1-depletion [average fork rate: 0.58kb/min vs 0.74kb/min (p=0.046) for CIdU tracks and 0.49kb/min vs 0.58kb/min (p=0.041) for IdU tracks in PIF1 and control siRNA treated HCT116 cells (Fig. 3A-I)].