Moreover, poly(I:C) also increased brain and skin gene expression of TNF-α, IL-6, KC, CCL2, CCL4, CCL5, CXCL10, while HDC and NT gene expression were only increased in the skin, suggesting that NT and histamine may explain the skin findings in CFS patients. Here, CXCL10 is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.