CD4 and rheumatoid arthritis: Moreover, the CD4 T helper (Th) subsets Th1 and Th17, which have been implicated in RA and other autoimmune diseases, express high levels of surface LTα1β2, and depletion of these cells with a murine anti-LTα-depleting antibody has demonstrated therapeutic efficacy in preclinical murine models of RA [4].