Further evidence for a relation between LEPR and fat-related traits is available from the literature, i.e. a highly significant differential expression of LEPR in muscle tissue of pig breeds that display divergent obesity traits was reported by [66] and an association between a non-coding variation in LEPR and higher BMI was demonstrated in Native Americans [67]. The gene discussed is LEPR; the disease is obesity due to melanocortin 4 receptor deficiency.