We showed that the prevalence of ABPA in COPD patients, in those with elevated serum IgE, and in those with Aspergillus sensitization was 2.9%, 6.2%, and 19.5% respectively, indicating that the occurrence of ABPA in COPD was lower than that in asthma [3,19]. This evidence concerns the gene IGHE and chronic obstructive pulmonary disease.