IGHE and chronic obstructive pulmonary disease: Our study showed that the prevalence of Aspergillus sensitization in patients with COPD was 15%, similar to that reported by Bafadhel et al., but higher than that by Agarwal et al. Besides the different study subjects, different methods to determine Aspergillus sensitization may be a main reason for the discrepancy, because detection of specific IgE (used in our study) has been shown to be more sensitive than SPT (used by Agarwal) to identify Aspergillus sensitization [12,21,22].