Interestingly, several Alzheimer’s disease related genes (PSEN1, SORL1, FGFR1, BMP7, FYN, BCL2, SCD, NPC2, PTBP1, TNFRSF1A, ITGB1, LHPP, LRP2, LRPAP1, LPL, L1CAM, CNNM1 and HSPA12A) had hub gene status in this HD/PD consensus network (Figure 6E-G). Here, TNFRSF1A is linked to early-onset autosomal dominant Alzheimer disease.