Therefore, modulation of transcription factors, not yet implicated in HD, like certain members of the STAT transcription factor family (immune response), TCF3 (immune response), TCF12 (lineage-specific gene expression, initiation of neuronal differentiation), EGR1 (differentiation, mitogenesis), EGR2/4 (immune response), IRF1 (immune response, apoptosis), GABPB1 (mitochondrial function), or PAX4 (development, tumorigenesis) could lead to new strategies towards slowing down pathogenesis in Huntington’s disease. This evidence concerns the gene IRF1 and Huntington disease.