Therefore, modulation of transcription factors, not yet implicated in HD, like certain members of the STAT transcription factor family (immune response), TCF3 (immune response), TCF12 (lineage-specific gene expression, initiation of neuronal differentiation), EGR1 (differentiation, mitogenesis), EGR2/4 (immune response), IRF1 (immune response, apoptosis), GABPB1 (mitochondrial function), or PAX4 (development, tumorigenesis) could lead to new strategies towards slowing down pathogenesis in Huntington’s disease. The gene discussed is TCF3; the disease is juvenile Huntington disease.