PSEN1 and Alzheimer disease: Interestingly, several Alzheimer’s disease related genes (PSEN1, SORL1, FGFR1, BMP7, FYN, BCL2, SCD, NPC2, PTBP1, TNFRSF1A, ITGB1, LHPP, LRP2, LRPAP1, LPL, L1CAM, CNNM1 and HSPA12A) had hub gene status in this HD/PD consensus network (Figure 6E-G).