Interestingly, several Alzheimer’s disease related genes (PSEN1, SORL1, FGFR1, BMP7, FYN, BCL2, SCD, NPC2, PTBP1, TNFRSF1A, ITGB1, LHPP, LRP2, LRPAP1, LPL, L1CAM, CNNM1 and HSPA12A) had hub gene status in this HD/PD consensus network (Figure 6E-G). The gene discussed is CNNM1; the disease is early-onset autosomal dominant Alzheimer disease.