From the results shown in Figure 7 diabetes induction suppressed liver G6PDH expression by 1.79 folds; however, a 14-day intervention with MET, VA1 and VA2, up-regulated its expression by 1.42, 1.32 and 1.98 folds respectively, implying enhanced glucose utilization in PPP (Figure 7a). This evidence concerns the gene H6PD and diabetes mellitus.