We have also reported an association between maspin expression and clinicopathological factors in several types of cancer such as breast cancer [8-10], colorectal cancer [11], endometrioid endometrial carcinoma [12] and ovarian mucinous borderline tumor [13], and have suggested that cytoplasmic maspin expression may be an indicator of poor prognosis. This evidence concerns the gene SERPINB5 and colorectal cancer.