Notably, genes identified in the in vitro RNAi screen have been implicated in susceptibility to SCZ (SEC16B and CAECAM21), ASD (FHIT) and MDD (SHIP1 and FHIT) by genome-wide association studies (GWAS) in humans; the same holds for ARNTL and RORA, which are associated with SCZ. The gene discussed is FHIT; the disease is major depressive disorder.