Furthermore, we suggest that MIB-1 labeling index might be useful and adjunctive aids for recognizing no evidence of malignancy and reaching the correct diagnosis of cutaneous BL, as well as modestly atypical lining endothelial cells with mildly pleomorphic nuclei, but no apparent mitotic figure, especially in case of small or inadequate specimens. This evidence concerns the gene MIB1 and Burkitt lymphoma.