Furthermore, the tumor cells of both the first and follow-up biopsy specimens showed strong immunohistochemical expression of lymphatic vessel endothelial hyaluronan receptor (LYVE)-1 (LYVE-1; R&D Systems, Inc., Minneapolis, MN, USA, diluted 1:320) (Figure 3A) and lower MIB-1 (Ki67; DAKO, diluted 1:50) labeling index, less than 1% (0.3%) (Figure 3B). This evidence concerns the gene LYVE1 and neoplasm.